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Exploitation of the initiation of DNA replication for the treatment of pancreatic cancer

Recipient: Dr Steve Pereira

Host Institution: University College London

Title: Exploitation of the initiation of DNA replication for the treatment of pancreatic cancer

Type of award: 2009 Research Grant

Funding: £140,210 awarded over two years

This project will attempt to define whether a new molecular pathway can be targeted using a new generation of drugs to treat pancreatic cancer. The pathway is involved in starting the process of DNA replication which is sped up in cancer cells. Tissue samples taken from patients who have previously had biopsies or operations for pancreatic cancer will be used to investigate this molecular pathway in more detail, using a number of techniques. Specific treatments that block this pathway will be used to attempt to kill pancreatic cancer cells in the laboratory.