Regression Evaluation of pancreatic cancer using Single-cell sPatial multi-Omics following Neoadjuvant therapy for Survival Enhancement (RESPONSE)
Review a project summary to ask can we study diagnostic biopsies to better understand patients’ response to chemotherapy given before surgery.
The project
Dr Nigel Jamieson and Dr Mari-Claire McGuigan are from the University of Glasgow and submitting a grant application that they would like your feedback on.
Patients with pancreatic cancer who are planned for an operation often have chemotherapy prior to the operation. There are different regimes of chemotherapy that can be given, and the goal is to be as precise as possible for each patient.
Patients who are planned for surgery will have a biopsy prior to the operation during an endoscopic ultrasound. Dr Nigel Jamieson and Dr Mari-Claire McGuigan want to look at the biopsies from which the diagnosis of pancreatic cancer was made and study the way the cells communicate and are positioned using a molecular microscope to better understand which patients’ tumours respond to chemotherapy.
This means there is no extra invasive procedure for the patient. This will help them develop the right test to study biopsies in the future so that the chemotherapy given can be much more precise. In the longer term, they would aim to apply these tests to the cancer removed at the time of surgery too, to decide on precise chemotherapy for patients after surgery.
Next steps
No scientific background or prior experience is needed to take part in this opportunity.
If you would like to give your feedback on this project, please contact the Research Team (research@pancreaticcancer.org.uk) quoting the involvement reference ‘Jamieson’. We will then email you the lay summary and specific questions Dr Victoria Hart would like you to consider. Please return your responses to the research team by Sunday 15th December 2024.
