Multiple endocrine neoplasia
This is a rare inherited condition that causes tumours to develop in endocrine glands. Endocrine glands produce hormones.
Type 1 (MEN1) is caused by faults in the MEN1 gene. Many tumours can develop in different glands, including the pancreas, the parathyroid gland and the pituitary gland. Up to 8 out of 10 people with MEN1 (80%) are at risk of developing PancNETs.
Type 4 (MEN4) is even rarer and can also cause tumours in the pancreas. Its symptoms are similar to MEN1 but it is caused by faults in the CDNK1B gene.
Genetic screening should be offered to people with MEN1 and their first-degree relatives. Follow-up should include annual blood tests and MRI, EUS and/or CT scans every 1-3 years. Read about these scans.