What if my pain relief isn’t working?

On this page we explain what to do if your pain relief isn’t working.

What can help if my pain relief isn’t working?

Don’t wait to ask for help with pain. Tell your doctor or nurse straight away if your pain gets worse or is not being controlled.

Your doctor or nurse may increase the dose of your painkillers or change the way you take them. Or they may suggest switching to a different painkiller.

If your pain isn’t under control, it may help to have a specialist palliative care or supportive care review. Your GP or hospital team can refer you for this. Read about palliative care and supportive care.

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“ You don’t have to endure pain without help or medication. You don’t have to put up with it."

Questions to ask your doctor or nurse


  • Can you explain how and when I should take painkillers?
  • What side effects might I get?
  • Should I take anything to prevent side effects?
  • Will other medicines affect my pain relief?
  • How will these painkillers affect my daily life?
  • Can I drive if I’m taking opioid painkillers?
  • What should I do if the pain doesn’t get better or gets worse?

Speak to our specialist nurses about pain

You can speak to our specialist nurses on our free Support Line with any questions about pain and how it can be managed.

Speak to our nurses

Updated April 2025

To be reviewed April 2028