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Information about the supply of Creon 25,000 and Nutrizym

Specialist nurse, Lynne, provides information following an update in December 2023 about the supply of Creon 25,000 and Nutrizym.

Hello, I am Lynne, a specialist pancreatic cancer nurse. This blog is to provide you with some information following an update in December 2023 about the supply of Creon® 25,000.  We have also been made aware of some problems with the supply for Nutrizym®.

Pancreatic enzyme replacement therapy (PERT) is a capsule you take with food that helps to replace the enzymes your pancreas would normally make. They help you to digest your food and absorb all the calories and nutrients. Brands of PERT include Creon and Nutrizym. The companies that produce these PERT capsules have warned of a temporary shortage of Creon 25,000 and Nutrizym over the coming weeks. The company that makes Creon is called Viatris, and Zentiva makes Nutrizym. They have both told us that they are working hard to sort out these issues.

There may be some areas in the UK not affected by this shortage, so it may be that you aren’t affected at all.

If you take Creon 25,000 and are affected by this shortage, there are also Creon 10,000 capsules. You can use these safely to make up your dose. This would mean having to take more capsules to make up your normal dose. For example, if you normally take 75,000 with your meals (so three 25,000 capsules normally) you may need to take seven 10,000 capsules. This may seem a lot to take in one go. If you struggle taking them all at once you may prefer to spread them throughout your meal. You can also use a mixture of 25,000 and 10,000 safely if you have both capsules. Some people will benefit from using smaller capsules for snacks and smaller meals.

If your normal pharmacy doesn’t have supply of your PERT, you could try calling other pharmacies in the area to see if they do. Or you could check back in a couple of days as we understand pharmacies are restocking with fresh supplies regularly. You could also ask your pharmacy to try calling the company that makes your PERT to have more stock sent.

There is also another brand of pancreatic enzyme replacement capsules called Pancrex®. This may be an option if your pharmacy can’t restock your current prescription. You would need to talk to your GP to get a new prescription for a different enzyme capsule.

Get support with your PERT

If you are unsure what this means for you, please get in touch with your dietitian, hospital team or GP. They will be able to give you advice. You can also contact our specialist nurses on the Support Line for information. Read more about taking PERT.

"Thank you for your help and advice this morning. This led me to getting a prescription for Creon filled this afternoon, after speaking to the pharmacist at my GP practice about what the pharmaceutical company had told you about supplies."

We understand that if you take Creon or Nutrizym, you might feel worried about not being able to get your usual prescription. Please don’t feel you need to stockpile by getting extra supplies, as this may cause further shortages and we are assured that this is a short term problem.

Action we’re taking on access to PERT

We know how important being able to access PERT is, and that there have been repeated issues that have cropped up over the past years. In the past, we’ve campaigned to improve access, and we want to reassure you that we know how important it is to stop the uncertainty people have been facing.

That’s why we’ve been raising these issues as a matter of priority with government officials and decision-makers again, so we can push them and companies to resolve these problems once and for all.

Remember, you can get information on taking PERT from our specialist nurses on our Support Line. You can get in touch by email or pick up the phone and call them free on 0808 801 0707.

Thanks for reading the blog, I hope you’ve found it helpful.


Updated December 2023